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Study
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Subjects
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No. of subjects (female)
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Mean age (SD)
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Comorbid Depression
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Comorbid Agora-phobia
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Medication status
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Study paradigm
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Amygdala
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Hippocampus
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Ventromedial Prefrontal cortex
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Other brain regions
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|---|
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Tanii, 2009 [24]
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PD
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71 (52)
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37.9
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Genotyping (COMT Val158Met polymorphism)
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Met/Met, n = 8
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-
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-
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-
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Right LPFC O2Hb▲ in Met/Met
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Val/Met, n = 29
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Val/Val, n = 34
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Dresler, 2009 [25]
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PD
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1 (0) Case study
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44
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Current
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Medicated with doxepine, zopiclone and amitriptyline
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Emotional Stroop task with words (Neutral/panic-related), before/after repetitive transcranial magnetic stimulation (rTMS) treatment to left PFC
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-
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-
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-
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Neutral/panic-related: DLPFC O2Hb▲ after rTMS treatment (small superiority for Panic-Related)
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Akiyoshi, 2003 [26]
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PD
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23 (12)
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26.5 (7.6)
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None
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Current, n = 14
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Alprazolam/paroxetine, n = 19
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Presentation of visual stimuli (Neutral/anxiety-relevant/ anxiety-irrelevant but emotion-relevant)
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-
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-
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-
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Anxiety-relevant/ anxiety-irrelevant but emotion-relevant: left frontal O2Hb▼ |
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HC
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31 (15)
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24.1 (6.4)
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- Abbreviations: DLPFC, dorsolateral prefrontal cortex; HC, healthy control; LPFC, lateral prefrontal cortex; Met, methionine; O
2
Hb, oxygenated hemoglobin; PD, panic disorder; PFC, prefrontal cortex; SD, standard deviation; Val, valine.
