Table 3 Summary of the studies which included P200 component
From: Event-related potential studies of post-traumatic stress disorder: a critical review and synthesis
| Study | Study Groups | Paradigm | Findings |
|---|---|---|---|
| [31] |
12 combat PTSD veterans 6 normal controls | Four tones intensity paradigm | Reduced P2 amplitude intensity slope in PTSD subjects |
| [25] |
13 female with sexual assault PTSD 16 healthy controls | Auditory oddball | Reduced amplitude and latency in response to deviant stimuli |
| [28] |
17 civil PTSD 17 healthy controls | Auditory oddball | Smaller P200 to target and common tones. Earlier response to common but not target tones. |
| [30] |
36 civil PTSD 20 healthy 10 depressed 8 alcoholics. | 2000-Hz tone presented in intensity blocks of 65, 72.5, 80, 87.5, and 95 dB (SPL) | In normal subjects, depressed, and alcoholics, there was linear relationship between the tone intensity and P200 amplitude, which was not the case in combat related PTSD subjects. |
| [32] |
29 PTSD nurse veterans 38 non-PTSD | Four-tone stimulus-intensity modulation paradigm | Increased P2 amplitude/intensity slope |
| [35] |
10 civil PTSD 10 controls | Auditory oddball | No difference in P2 amplitude or latency |
| [29] |
7 PTSD motor vehicle accident (MVA) 7 non-PTSD with MVA | Visual presentation of trauma related/unrelated/neutral pictures |
Smaller P200 amplitude Larger response to trauma-related images in non-PTSD and healthy controls |
| [36] |
14 PTSD [mixed etiologies] 12 controls | Auditory oddball | No difference in P200 amplitude |
| [33] | 12 combat exposed veterans with PTSD and 33 without PTSD and their twins | Four-tone stimulus-intensity modulation paradigm |
Increased P2 amplitude intensity slope in PTSD veterans. P2 amplitude intensity slopes were related to higher combat exposure, CAPS Total, and re-experience symptoms severity scores in the combat-exposed veterans but not to the remaining PTSD symptom cluster scores or the SCL-90-R (Symptom Checklist 90 Revised) general psychopathology, anxiety, or depression subscale scores. Higher combat-exposure scores, but not CAPS Total or subscale scores, were also related to increased P2 amplitude. |
| [34] | 12 PTSD and 12 control survivors of earthquake | Subliminal visual presentation of earthquake-related/unrelated words | Increased P2 amplitude in the PTSD group in response to the trauma-related stimuli |